For early infant diagnosis, DBS has a sensitivity of 100% compared to fresh whole blood or plasma in all studies.Īlthough limited data are available for EID, DBS offer a highly sensitive and specific sampling strategy to make viral load monitoring and early infant diagnosis more accessible in remote settings. The systematic review showed that specificity was close to 100% at DBS VL above 5000 copies/ml, and this threshold would be the most reliable for predicting true virologic failure using DBS.
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Unlike a plasma VL test which measures only cell free HIV RNA, a DBS VL also measures proviral DNA as well as cell-associated RNA, potentially leading to false positive results when using DBS. Sensitivity of DBS VL was found to be 78-100% compared to plasma at VL below 1000 copies/ml, but this increased to 100% at a threshold of 5000 copies/ml. Get tickets for Marco Antonio Solís - El Buki World Tour 2023 promoted by Live Nation at T-Mobile Arena in Las Vegas, NV on Fri, 8:00PM at AXS. Because the input sample volume is much smaller in a blood spot, there is a risk of false negatives with DBS. Depending on the technology and the viral load distribution in the study population, the percentage of DBS samples that are within 0.5 log of VL in plasma ranged from 52-100%. Thirteen peer reviewed HIV VL publications and five HIV EID papers were included. We systematically reviewed evidence on the performance of DBS compared to plasma for VL monitoring and EID. 11 Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom.ĭried blood spots (DBS) have been used as alternative specimens to plasma to increase access to HIV viral load (VL) monitoring and early infant diagnosis (EID) in remote settings.10 Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa.
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